What is Clomifene?
Clomifene, also known as clomiphene, is a medication used to treat infertility in women who do not ovulate. This includes those who have polycystic ovary syndrome. Use leads to a more extensive prospect of twins. It’s taken by mouth once each day.
Clomid is a popular brand name and nickname for most generic clomiphene citrate. It’s an oral fertility medicine approved by the U.S. Food and Drug Administration (FDA) to be used in women who cannot become pregnant. It impacts the hormone balance in the body and promotes ovulation.
- Molar mass: 405.966 g/mol
- Formula: C26H28ClNO
- Trade name: Clomid
- Excretion: Mainly urine, a few in bile
- Elimination half-life: 5–6 days
How can Clomid work?
Clomid blocks the hormone estrogen by interacting with your pituitary gland. When estrogen communicates with the pituitary gland, not as luteinizing hormone (LH) and follicle-stimulating hormone (FSH) are generated. This leads to a drop in testosterone and therefore decreased the production of semen. Since Clomid blocks estrogen’s interaction with the pituitary gland, there’s an increase in LH, FSH, and testosterone within the human body.
When is Clomid prescribed?
Clomid is prescribed off-label for male infertility, especially where reduced testosterone levels are observed. According to the U.S. Centers for Disease Control and Prevention, both the man and a female factor are identified in 35% of couples that struggle to conceive. In 8% of couples, just a male element is detected.
Lots of things can contribute to infertility in both men. These include –
- Harm to the testicles
- Excess weight or obesity
- Hormonal imbalance, due to improper function of the adrenal gland or exposure to too much estrogen or testosterone
- Medical ailments, such as diabetes, cystic fibrosis, and some types of autoimmune disorders
- Cancer treatment involving certain Kinds of radiation or chemotherapy
- Varicoceles, which are enlarged veins which cause the testicles to overheat
- Genetic disorders, like a microdeletion in the Y-chromosome or Klinefelter syndrome
If your doctor suspects male infertility, they’ll order a semen evaluation. Your physician will use a sample of your semen to assess the sperm count in addition to sperm form and movement.